Hematología: Williams Hematology, Eighth Edition

Williams Hematology, Eighth Edition

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. The book begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.
Featuring a brand-new full-color presentation, the Eighth Edition of Williams Hematology is extensively revised to reflect the latest views of experts in the field. Two new chapters examine the importance of genomics in hematology and cell therapy for tissue replacement, whereas other chapters have been revised to incorporate the newest clinical approaches to the leukemias and lymphomas, and the application of targeted therapy in the treatment of hematologic disorders.

Contents:
Part I. Clinical Evaluation of the Patient
Chapter 1 Initial Approach to the Patient: History & Physical Examination
Chapter 2 Examination of Blood Cells
Chapter 3 Examination of the Marrow

Part II. The Organization of the Lymphohematopoietic Tissues
Chapter 4 Structure of the Marrow & the Hematopoietic Microenvironment
Chapter 5 The Organization & Structure of Lymphoid Tissues

Part III. Epochal Hematology
Chapter 6 Hematology of the Fetus & Newborn
Chapter 7 Hematology during Pregnancy
Chapter 8 Hematology in Older Persons

Part IV. Molecular & Cellular Hematology
Chapter 9 Genetic Principles & Molecular Biology
Chapter 10 Genomics & Epigenetics
Chapter 11 Cytogenetics & Molecular Abnormalities
Chapter 12 Apoptosis
Chapter 13 Cell-Cycle Regulation & Hematologic Disorders
Chapter 14 Signal Transduction Pathways
Chapter 15 The Cluster of Differentiation Antigens
Chapter 16 Hematopoietic Stem Cells, Progenitors & Cytokines
Chapter 17 The Inflammatory Response
Chapter 18 Innate Immunity
Chapter 19 Dendritic Cells & the Control of Innate & Adaptive Immunity

Part V. Therapeutic Principles
Chapter 20 Pharmacology & Toxicity of Antineoplastic Drugs
Chapter 21 Principles of Hematopoietic Cell Transplantation
Chapter 22 Treatment of Infections in the Immunocompromised Host
Chapter 23 Principles of Antithrombotic Therapy
Chapter 24 Principles of Immune Cell Therapy
Chapter 25 Principles of Vaccine Therapy
Chapter 26 Principles of Therapeutic Apheresis: Indications, Efficacy & Complications
Chapter 27 Principles of Gene Transfer for Therapy
Chapter 28 Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement

Part VI. The Erythrocyte
Chapter 29 Morphology of the Erythron
Chapter 30 Composition of the Erythrocyte
Chapter 31 Production of Erythrocytes
Chapter 32 Destruction of Erythrocytes
Chapter 33 Clinical Manifestations & Classification of Erythrocyte Disorders
Chapter 34 Aplastic Anemia: Acquired & Inherited
Chapter 35 Pure Red Cell Aplasia
Chapter 36 Anemia of Chronic Renal Disease
Chapter 37 Anemia of Chronic Disease
Chapter 38 Anemia of Endocrine Disorders
Chapter 39 The Congenital Dyserythropoietic Anemias
Chapter 40 Paroxysmal Nocturnal Hemoglobinuria
Chapter 41 Folate, Cobalamin & Megaloblastic Anemias
Chapter 42 Disorders of Iron Metabolism
Chapter 43 Anemia Resulting from Other Nutritional Deficiencies
Chapter 44 Anemia Associated with Marrow Infiltration
Chapter 45 The Red Blood Cell Membrane & Its Disorders: Hereditary Spherocytosis, Elliptocytosis & Related Diseases
Chapter 46 Disorders of Red Cells Resulting from Enzyme Abnormalities
Chapter 47 The Thalassemias: Disorders of Globin Synthesis
Chapter 48 Disorders of Hemoglobin Structure: Sickle Cell Anemia & Related Abnormalities
Chapter 49 Methemoglobinemia & Other Dyshemoglobinemias
Chapter 50 Hemolytic Anemia Resulting from Physical Injury to Red Cells
Chapter 51 Hemolytic Anemia Resulting from Chemical & Physical Agents
Chapter 52 Hemolytic Anemia Resulting from Infections with Microorganisms
Chapter 53 Hemolytic Anemia Resulting from Immune Injury
Chapter 54 Alloimmune Hemolytic Disease of the Fetus & Newborn
Chapter 55 Hypersplenism & Hyposplenism
Chapter 56 Primary & Secondary Polycythemias (Erythrocytosis)
Chapter 57 The Porphyrias
Chapter 58 Hereditary & Acquired Sideroblastic Anemias

Part VII. Neutrophils, Eosinophils, Basophils & Mast Cells
Chapter 59 Morphology of Neutrophils, Eosinophils & Basophils
Chapter 60 Composition of Neutrophils
Chapter 61 Production, Distribution & Fate of Neutrophils
Chapter 62 Eosinophils & Their Disorders
Chapter 63 Basophils & Mast Cells & Their Disorders
Chapter 64 Classification & Clinical Manifestations of Neutrophil Disorders
Chapter 65 Neutropenia & Neutrophilia
Chapter 66 Disorders of Neutrophil Function

Part VIII. Monocytes & Macrophages
Chapter 67 Morphology of Monocytes & Macrophages
Chapter 68 Biochemistry & Functions of Monocytes & Macrophages
Chapter 69 Production, Distribution & Fate of Monocytes & Macrophages
Chapter 70 Classification & Clinical Manifestations of Disorders of Monocytes & Macrophages
Chapter 71 Monocytosis & Monocytopenia
Chapter 72 Inflammatory & Malignant Histiocytosis
Chapter 73 Lipid Storage Diseases

Part IX. Lymphocytes & Plasma Cells
Chapter 74 Morphology of Lymphocytes & Plasma Cells
Chapter 75 Composition & Biochemistry of Lymphocytes & Plasma Cells
Chapter 76 Lymphopoiesis
Chapter 77 Functions of B Lymphocytes & Plasma Cells in Immunoglobulin Production
Chapter 78 Functions of T Lymphocytes: T-Cell Receptors for Antigen
Chapter 79 Functions of Natural Killer Cells
Chapter 80 Classification & Clinical Manifestations of Lymphocyte & Plasma Cell Disorders
Chapter 81 Lymphocytosis & Lymphocytopenia
Chapter 82 Immunodeficiency Diseases
Chapter 83 Hematologic Manifestations of Acquired Immunodeficiency Syndrome
Chapter 84 Mononucleosis Syndromes

Part X. Neoplastic Myeloid Diseases
Chapter 85 Classification & Clinical Manifestations of the Clonal Myeloid Disorders
Chapter 86 Polycythemia Vera
Chapter 87 Essential Thrombocythemia
Chapter 88 Myelodysplastic Syndromes (Clonal Cytopenias & Oligoblastic Myelogenous Leukemia)
Chapter 89 Acute Myelogenous Leukemia
Chapter 90 Chronic Myelogenous Leukemia & Related Disorders
Chapter 91 Primary Myelofibrosis

Part XI. Neoplastic Lymphoid Diseases
Chapter 92 Classification of Malignant Lymphoid Disorders
Chapter 93 Acute Lymphoblastic Leukemia
Chapter 94 Chronic Lymphocytic Leukemia & Related Diseases
Chapter 95 Hairy Cell Leukemia
Chapter 96 Large Granular Lymphocytic Leukemia
Chapter 97 General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity & Primary Extranodal Disease
Chapter 98 Pathology of Malignant Lymphomas
Chapter 99 Hodgkin Lymphoma
Chapter 100 Diffuse Large B-Cell Lymphoma
Chapter 101 Follicular Lymphoma
Chapter 102 Mantle Cell Lymphoma
Chapter 103 Marginal Zone B-Cell Lymphomas
Chapter 104 Burkitt Lymphoma
Chapter 105 Cutaneous T-Cell Lymphoma (Mycosis Fungoides & Sézary Syndrome)
Chapter 106 Mature T-Cell & Natural Killer Cell Lymphomas
Chapter 107 Plasma Cell Neoplasms: General Considerations
Chapter 108 Essential Monoclonal Gammopathy
Chapter 109 Myeloma
Chapter 110 The Amyloidoses
Chapter 111 Macroglobulinemia
Chapter 112 Heavy-Chain Disease

Part XII. Hemostasis & Thrombosis
Chapter 113 Megakaryopoiesis & Thrombopoiesis
Chapter 114 Platelet Morphology, Biochemistry & Function
Chapter 115 Molecular Biology & Biochemistry of the Coagulation Factors & Pathways of Hemostasis
Chapter 116 Control of Coagulation Reactions
Chapter 117 Vascular Function in Hemostasis
Chapter 118 Classification, Clinical Manifestations & Evaluation of Disorders of Hemostasis
Chapter 119 Thrombocytopenia
Chapter 120 Reactive Thrombocytosis
Chapter 121 Hereditary Qualitative Platelet Disorders
Chapter 122 Acquired Qualitative Platelet Disorders
Chapter 123 The Vascular Purpuras
Chapter 124 Hemophilia A & Hemophilia B
Chapter 125 Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI & XIII & Combined Deficiencies of Factors V & VIII & of the Vitamin K-Dependent Factors
Chapter 126 Hereditary Fibrinogen Abnormalities
Chapter 127 von Willebrand Disease
Chapter 128 Antibody-Mediated Coagulation Factor Deficiencies
Chapter 129 Hemostatic Dysfunction Related to Liver Diseases & Liver Transplantation
Chapter 130 Disseminated Intravascular Coagulation
Chapter 131 Hereditary Thrombophilia
Chapter 132 The Antiphospholipid Syndrome
Chapter 133 Antibody-Mediated Thrombotic Disorders: Thrombotic Thrombocytopenic Purpura & Heparin-Induced Thrombocytopenia
Chapter 134 Venous Thrombosis
Chapter 135 Atherothrombosis: Disease Initiation, Progression & Treatment
Chapter 136 Fibrinolysis & Thrombolysis

Part XIII. Transfusion Medicine
Chapter 137 Erythrocyte Antigens & Antibodies
Chapter 138 Human Leukocyte & Platelet Antigens
Chapter 139 Blood Procurement & Screening
Chapter 140 Red Cell Transfusion
Chapter 141 Preservation & Clinical Use of Platelets

Autores: Kenneth Kaushansky, Ernest Beutler, Uri Seligsohn, Marshall A. Lichtman, Thomas J. Kipps, Josef T. Prchal
Edición: 8ª
Año: 2010
Páginas: 2460
ISBN-10: 0071621512
ISBN-13: 978-0071621519


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